Would people think that it would be a good idea if you were allowed to carry more items than three in your inventory but you would become "Burdened" and could only move 1 space per move action?
Also if you were addicted and carrying a large amount of drugs you would also be Burdened if you had more than three.
This would bring the board game more in line with the video game. I remember totally looting the Enclave's HQ in Fallout 3 and slowly walking all the way back to Megaton so I could sell everything :-)