Cruise Missiles and Harpoon Missiles are the current favourites when it comes to dropping payloads, for good reason.
But would they still be the number one picks if all other ordnance lost the "Spend Your Target Lock" wording? I think probably so; Cruise can generate up to 5 attack dice, Harpoon has the condition/splash damage, and both are very competitvely priced. There's a couple of other missiles which allow you to retain your Target Lock - due to price, range restrictions or role, Homing, Advanced Homing and Ion Pulse all only really see niche use, even with the benefit of rerolls.
So is the "Spend Your Target Lock" restriction out of date now? Would removing the restriction from upgrades like Plasma and Proton Torpedoes, Concussion or Cluster Missiles make a significant impact on their usage, or just open up a bit more variety in list building?