First off, I was surprised at the number of cards, I wasn't expecting 14 of them.
Here are my thoughts:
Heroic Rescue: I like it, not sure I would choose it over Dodge, but I would definitely choose it in addition to Dodge. I think it gets a bump with Zoey.
Combat Training: Kind of meh. Guardians don't normally need a boost to fight if they have high xp weapons. They also tend to be short on resources. The access to a dex boost is unusual for Guardians and I like having that option, although once again, Guardians don't need to boost agility to much and can't afford the resources. Skids may get a fair amount of mileage out of this (but I also like Moxie).
Anatomical Diagrams: Not bad, not sure how often I would find room in my deck for it. Also, I feel an Unexpected Courage would be more versatile and net similar effects most of the time. (not always since I could UC and AD into another investigator's check.)
Scientific Theory: This one I like for Daisy, it would have changed how I built her deck. For Rex and Minh, I feel they are better off with Fire Axe and Higher Education. There is some potential for Roland on this one but I never have enough xp with Roland.
Knuckleduster: I am on the fence and would love feedback. I think Zoe is best positioned to use this card. Jenny and Skids could get some decent use if they have fight boosts available. I think with his access to so many ammo weapons and extra ammo and contraband, it may be better to build Skids with ammo weapons rather than melee.
Moxie: I like it, helps Sefina and Skids a lot. Jenny has a lot of options with talent cards (7 of them at the moment). For Wendy, I feel she is better off with her natural redraw ability and spending her resources on events than using talents in general.
Renfield: I like him a lot. I feel like we are getting enough diversity in mystic cards to go different ways. Plus I like power at a price cards. Resources is quickly becoming an issue in the rearview mirror for mystics.
Grounded: Pretty good. We are getting to a point where we can have mystics forgo the expensive high level spells and just use cheaper cards to boost their lower level spells (see Spirit Athame).
Cherished Keepsake: Its as good as Leather Jacket and I love Leather Jacket.
Plucky: Pretty good and synergies well with Scrapper. Plus Survivors have all those resources handy.
All the neutral skills: Still getting my head around them. Clearly, they are good with those low Sanity investigators. Trying to figure out in what situations/decks I would swap them for the core box skills. You do run the risk of having a lot of cards that you can't play until you take damage so I would use them sparingly. For Mark, I probably wouldn't use Reckless Assault, but may use Say Your Prayers or Run For Your Life.