I have persuaded my brother to take a punt with the game (he is a keen gamer generally) and suddenly realised that this, more than any other LCG/CCG, is perfect for skype play without a computer program.
As far as I can tell you can have any number of players with their decks at different locations. The locations/agenda/act out as the scenario prescribes and each with their own setup Chaos bag. Then one player controls the encounter deck (and the others have their encounter cards in order) and when encounter cards are drawn it is 'Roland has 'flesh eater' card 45' and so on. Over the skype connection then actions are described and the board state is verbally kept in sync. No real need to keep player state in sync.
I think this could even help with roleplaying as yopu cannot look over and 'see' what a player has available so as to give handy hints.
Have I missed anything or is this as viable as I think it is for long distance play..