Don't have no disintegrations yet but does this work?
So a cybered out Gadgeteer/martial artist/doctor
with pressure point, deadly accuracy and martial grace can potentially add 18 damage if they have 6 ranks in brawl coordination and medicine?
So with 7 brawn you can now strike for 25 strain + successes
If you have 2 ranks in iorn body and roll 3 advantage you can trigger overpower with precision strike improved and attack again, though I guess that would make you two punch man.