With the Base Game you could play 4 Players if you bought a second copy. Any reason/need to own more than one copy of The Dunwich Legacy Expasion?
The Dunwich Legacy: How many copies?
I'm picking up two, but that's because I want a full playset of cards for 2 people. Everything from here on in should give you two copies of each player card, so you'll only need extra copies if you're not proxying and are fighting over cards from a certain class. Like say you have two characters that can use rogue cards and both players want a copy of liquid courage for whatever reason..
If you're the kind of person that bought 4 core sets, you'll want 2 copies of Dunwich so you can maintain 4 copies of each card. Otherwise, one copy is good enough.