Just fielding a scenario. The Maimed critical injury removes a limb. The effects prevent the character from doing anything requiring that limb, and "all other actions gain [setback]."
Say a PC loses (or chooses to begin without) one arm, and the player, for one reason or another, chooses not to replace the limb and remains one-armed. Would the character sustain this critical injury without being able to heal it (thus subjecting them to the +10 modifier on crit rolls), or remove the injury but keep the effect?
Alternatively, would you apply a different effect entirely?