I'm about to be starting a new campaign and am wavering back and forth on which sub-sector to base the game out of. Without going into details, the characters will be high ranking, Ordos Xenos affiliated. They're not subject to any real directive from a senior figure outside the PCs (No NPC telling them what to do, sending them on missions etc.). They're thus free to investigate and prosecute where and how they like.
I'm currently leaning towards the Malfian Sub-Sector as the setting for the campaign. I am, however, torn between it and Hazeroth.
Malfian: Maflian noble politics and shenanigans allow for just about any Inquisitorial investigation, conspiracies etc. Seedworld AFG, NNX215and Xeiros Prime are both forbidden, giving potential plotlines out of them. Two war worlds, Close to both the Halo Stars and The Periphery for Xenos/extra-imperium threats and antagonists. Including Rogue Trader and, eventually, Deathwatch with extra Xenos goodness. Fydae System Piracy. Remote from Scintilla prime but not too far for increased factional conflict.
Hazeroth:
Hazeroth Abyss, Malfi, close to the Fydae great cloud, Bloodfall & Phagir grouping of dead worlds. Very remote so group would be more removed from Scintilla support.
If anyone has any recommendations for why their favourite sub-sector is the best place to run a campaign then I'd love to read them.