Anyone try this?

By Veet, in Arkham Horror Second Edition

Just out of curiosity has anyone ever played a game with the Discomforting difficulty level card and Ghatanothoa as the Ancient One? It occurs to me that particular combination might actually have the opposite of the intended effect of the difficulty card.

Well, you're not forced to take all the Clues, though I wouldn't pass on taking all the Clues in most cases.

Against Yibb-Tstll the difficulty card could have a vastly detrimental effect.