With a few games of the new edition under my belt, I can say that I like what I see. My group includes some Cthulhu veterans and after the game we discussed our greatest memories playing Lovecraftian games. Someone mentioned playing an role-playing game scenario set on a luxury train. That got me thinking, why not in Mansions?
I humbly suggest a set of map tiles and an accompanying scenario that takes place (mainly) on a train. A 1920's luxury train was THE way to travel across the continent and a constantly moving, enclosed setting would make great narratives. There are opportunities for investigation (Agatha Christie's Orient Express anyone?), action (Trying to reach the locomotive through a train filled with cultists) and occult horror (An angry monster chasing the investigators through the train's narrow corridors.
Period luxury trains had many interesting cars that would make for interesting map tiles and some could double as small building on other scenarios (the restaurant car could act as a small cafe for example). There is almost a glut to choose from, with the engine, sleeper car, luxury passenger car with ample amenities, a second class passenger car, the private car for the rich and powerful, the restaurant car, a cargo car and of course, the caboose.
In some scenarios, the investigators (or monsters) could try to disconnect the cars, in others maybe the train makes a stop, allowing for interesting ways to interact with the environment?