So we all know you can lose without having a turn ...
... have Father Dagon as the Herald, have the first pre-game Mythos card open a gate on Devil Reef, have the second (thankis to Father Dagon's text) pre-game Mythos card cause a Monster Surge, with 6+ monsters now on Devil Reef they all move into the rift and fill the Deep One Rising Track instantly, if Azathoth is the Ancient One then game over ...
But is this scenario for winning the game without having a turn legal?
In a one player game, use Akachi Onyele as your Investigator. She starts the game with a gate trophy and if the pre-game Mythos card doesn't open a gate - say The Next Act Begins - then as the first turn starts you have 0 open gates and a number of gate trophies equal to the number of players ...

