I am having trouble deciding which expansion to play with for my next Solo Quest. I tried out the Cataclysm earlier, that was fun. I'd love to play with them all, but I don't have quite enough space for every expansion out at once. How do you decide which expansions to use in your Talisman experience?

I made rules for this its "Forever Talisman" https://community.fantasyflightgames.com/topic/176044-forever-talisman/

Rules for Cataclysm now. with some editing can be made for solo play. In fact that might be a good idea hmmmm.

1st Expansion City or Reaper.

City if you want an additional board. It is way different than the other expansions, adds a lot of new items and stuff!

Reaper expansion if you want a small expansion and no board. The Reaper adds more basic Adventure cards and a cool NPC character that runs around.

Next for an additional board I recommend the Highlands. Its great for beginning leveling and gets you gold for the city!

If you want a small expansion next, and already have the Reaper but don't have City, I recommend the Sacred Pool. As it gives not only great basic Adventure cards but also items from a stable deck you can purchase without having the city. If you do have the City I would recommend Frostmarch next as it also has a generic addition to the Adventure deck.

The next board expansion I recommend is the Dungeon. It is for higher level leveling.

The next board expansion I suggest is the Woodland expansion. It also is different than the others, though not like the City and I think it's fairly safe for low level characters. But it has a unique game play which seems fun.

Next I recommend Deep Realms which connects the City & Dungeon.

If you have the small expansions I listed above, I next recommend the Nether realm. This is a new different kind of expansion and gives you a really cool alternate ending, Pandora's Box.

The rest I would get in this order:

Firelands: has some really cool effects. And can be very dangerous if you have few expanions to water it down.

Bloodmoon: A very Halloweenish type expansion. Very strong in theme. I like the theme but only in the fall. It also has a game changing effect of creating day/night. In the day players get a +1 in battle at night enemies get a +1. You also get a werewolf NPC and Lycanthropy effects. I use only about 1/3 of the expansion (I don't use +1/-1 nor Lycanthropy). Others like it, but there is a strong percentage who think its fiddly.

The Dragon Expansion: Perhaps the most controversial expansion. About half the people do not like it. So lots of people play it with variations or house rules. It comes with a board, but it is an overlay for the center replacing part of the main board. I hated the expansion until I created a new way to play it, and now enjoy it a lot!

For a one-player adventure I think the Dragon expansion would be terrific. One of the things that turns people off of the Dragon is because it is "fiddly". With only one person controlling the actions it would be very easy to keep track of and moderate. It also adds a lot of cards and thematically makes the board feel like Dragons are lurking if not completely dominating the Talisman world.

Just my 2 cents.....