I was thinking of trying a progression-style playthrough, but everyone has done this and written about it so it is not so interesting. I thought that a very silly, probably non-feasible, but unusual approach would be to do the progression randomly. Every quest I pick at random from the full selection, and then I get to use forever the cards in that pack (or in the deluxe expansion, if such a quest is chosen). To make life a bit more plausible, I will allow myself to choose the number of players to use each quest, and give myself as many core sets as I want.
First up I randomly selected Flies and Spiders. This is a decent first choice. It gives me a full box of player cards, although most are not that useful at present because of lack of dwarfs. Still, Balin is a handy hero. More importantly, the quest doesn't require any monster-killing, so I can make up for the lack of attack strength in the core set by questing hard. My chosen deck was solo Eowyn/Beravor/Theodred, using 50 cards all from the Core Set. With a swift Forest Snare and a Gandalf killing Old Tom Noddy, I got through the first section with no active enemies. From there it was just a matter of freeing heroes, questing hard, and using Bilbo to defend everything I couldn't chump. With all the uses of the Magic Ring I ended up winning on 49 threat with loads of enemies engaged and ignored.
The next quest that has been selected for me is the Druadan Forest. The player cards for this set encourage mono-sphere, but I'm not sure that is the best idea. I quite like the Leadership event though, so I'll try one deck with Aragorn/Theodred/Balin (using Celebrian's Stone to add a few more cancels and Unexpected Courages) and put in Denethor into the other deck to provide a bit of defence and more Lore resources to play healing cards to counteract Archery. I am not convinced, but we'll see how it goes.