I played a game last night with:
Omega Leader, PtL, Comm Relay
Omega Ace, PtL
Epsilon Squadron Pilot
Soontir Fel, with Fel stuff
Vs:
Colonel Vessery, PtL, Ion Cannon, TIE Mk 2, TIE/D
2x Storm Squadron Pilot, Homing Missiles, TIE/x1, ATC
The Epsilon died early, when his block left him exposed, and the Baron nearly died to an early Range 3 Homing Missile (one crit got through: Direct Hit, which he carried for the rest of the game).
Other than that, things went well. I was able to set up several Range 1 three crit shots from Omega Ace, and Omega Leader did lots of work too. Part of the issue with him was that my opponent didn't realize going in that Omega Leader's ability would stop both ATC and Vessery's Target Locks. Certainly if two or more ships had focused on Omega Leader they could have burned him down without too much trouble, but he never seemed like the biggest threat, so while my opponent was chasing Baron Fel, the Omegas were able to predict who'd be shooting at them.
I might consider dropping the Comm Relay on Omega Leader for Weapon Guidance, because not wanting to spend my Target Lock left me with a blank and a hit several times.