I've never played epic, but I've been thinking about it a little since the Gozanti spoiler came out. It seems like TLT spam would be even more brutal in epic than regular play.
Is 12x Thug with TLT and Unhinged a list that ever gets used for epic? Even with reinforce, it seems like 24 TLT shots would melt any 0-agility huge ship. And vs small and large ships, TLT would be as effective as ever (worlds top 16) and seems like it would scale up better than most lists -- no unique pilots or upgrades that you can't duplicate, and no difficulty concentrating fire like other big swarms might have.
One issue could be Assault Missiles -- I'm not sure how much the presence of those shapes the battlefield in epic and how much they'd hurt comparative swarms like 12 Thugs. It wouldn't be nearly as bad as with TIE swarms, at least, since Y-Wings have lots of health. It might be worth replacing one of the Thugs with N'Dru + VI + Glitterstim + Assault Missiles for a high-PS Assault Missile shot to keep enemy groupings honest.