Well it doesn't have to be a warship, but has anyone ever played a game with the PCs in charge of a big ship (Silhouette 6 plus)? The sort of game where you make someone play as a Commodore, and then proceed to run every other sci-fi franchise (Battlestar Galactica, Babylon 5, Star Trek [except DS9]) through the viewpoint of Star Wars?
How did you run it? What was the ship? What roles did the PCs fill? What storylines did you use?
Or has nobody been brave/crazy enough to try this?