the MC-80 and ISD are basically centerpiece ships, they're not there to do something as basic as clobber something to death (the medium ships are more efficient for that); they're giant swiss army knives
for the MC-80, that means working with other squadrons and ships. With titles such as Independence and Home One such is obvious, but even Defiance indirectly "supports" your bombers by letting you lay waste to a ship in a single activation.
from what I can see, the MC-80 "template" is
Command Cruiser (106)
ECM (7)
Defiance/Independence/Home One
Boosted Comms if Defiance or Independence
[120-124]
run with 3/4 Silly H-6s if Defiance; B-wings if Independence
This thing isn't a hammer, it seems tailor made to operate behind a screen of some sort (definitely 3 Nebs, for me) and wreck havoc with its battery armaments (especially if enemies try to jump on your screen) and squadron cohorts
with squadron support, the large ships have the greatest chance in the game to wipe out an offending ship before it activates
remember, if you're just looking for a stick to whack someone with, the MC-80 is not your gal. She's more of an ornate plaque, a commanding focus of a room's decor upon which you can mount your opponent's skull
Edited by ficklegreendice