Between the targeted natural disasters, hostile animals, fantastic plant growth throwing off deadly spores, swarms of deadly insects, etc., I just don't see any PCs surviving, no matter where they go or what they do.
Even just the Tsunamies would wipe out the vast majority of populated locations on the globe.
This has got to be the most deadly setting I've ever come across. A quick TPK seems to be the only outcome. Why even bother running it?