I fully believe there are times when different experience levels can make a massive difference in the outcome.
I like the MtG references where you may be playing against an unknown but not have a clue how your opponent would react to certain things. Are they holding a counterspell just waiting to kill your game ender? Are they holding buffs to punish you for blocking and inversely how do they respond if you throw a bluff their way? It pays to know how your opponent plays.
I'm not certain how often the novice move can mess with a master's game in Chess but the master can certainly screw with a novice. Everyone knows the queen is the most valuable piece on a side so when one slides it up to sit diagonally in front of an enemy pawn you should know something big is up. Maybe it's a novice mistake that puts such an important piece into harms way but against anyone with experience that queen probably needs to be left alone. Of course my opponent nicely took the bait which moved the pawn out of blocking contention as a bishop slipped in front of the pawn and mated the opponent is a true fool's mate scenario.
In minis I've had an opponent stress so much over positioning a piece that has just telegraphing his plan. Of course he happened to miss a little extra movement potential on my side which caused his carefully constructed plan to completely fall apart.