I'm running the adventure, "Into the Maw" thats in the RT book. We all had a really good time and didn't run into any real problems. The game got really deadly when the baddies went from using suppressive fire to force pinning test , to full auto attacks after the players hit and took down the baddies boss lady. The explorers missionary started to move forward to get within flammer range when one of the baddies opend up with a full auto burst and hit with 5 of the 6 shots. I rolled a 10 on 4 of the 5 damage rolls and the missionary was reduced to a smoking corpse within 5 seconds. She had to burn a fate point in order to go from dying, to instead being 0 wounds and uncouncious.
One slightly annoying problem I ran into was that the players wanted to go on a shopping spree using acquisition test to buy a bunch of stuff in the book. Granted, most of it will not come for a week in game time, and they may be disappointed to learn they make have to leave before there stuff arrives, but it was still a little annoying. Thinking about putting a limit on aquisitions attempted per day or something.