So, I'll be honest. I'm pretty new at GM'ing, but have been a role-player for about 10 years now.
What is about to follow is merely my scribbles and thoughts on my campaign idea, and I welcome all you veteran GM's to give me your criticism. Remember, this is meant to help me with things I may have not even thought about, or round out the ones I have.
Player one the Space Pirate:
After many years of raiding and looting His Holy Emperors fleets and settlements, the Warp Cutter he was Quartermaster for was boarded by the navy, scuttled, and all crew who survived picked up and delivered to the nearest penal colony for processing. As the gears of the Adeptus Administratum turn ever slowly, he was left to his own devices within his cell block for the better part of a decade. As it so happens, the cell block was roughly the size of a small city, and the skills one learns as a pirate Quartermaster make one especially wealthy and influential within said environment.
Due to a uprising in another cell block, the Guard was called in to establish some order before the whole colony was reduced to utter anarchy. The 'War of District 16' was short, and bloody in part due to the slick negotiation and betrayal of our man to the Guard of key locations, personnel, and typical cache points used by the rebels.
Enter the Inquisition. (I haven't figured out a name for the Inquisitor yet, so we'll call him Bubba.) Bubba just so happens to be related to the Colony's Governor-Warden, and when he hears about this issues a pardon to our man 'In the name of the Holy Ordos' as he desperately needs 'Just the kind of expendable inventive feth heads like him for what I have in mind.'
Fast Forward 3 years and 5 months from then.
Our man finds himself at Port Wander: After having wheedled and cajoled, bribed, and when all else failed worked his way to said port with the only instructions to 'Dig in, and wait to be contacted'. That was 5 months ago, with still no formal contact from Bubba.
(Player 2 still hasn't really given me much to work with as far as her BG goes. It's going to be a smallish group, since I cant commit to anything more then a couple times a month)