I´ve been running our campaign since the Rulebook first came out, with the odd break, etc they are now up to over 8000 xp each and getting pretty powerful - or so they thought!
In preparation for Tattered Fates I ran a little scenario where they were hunting down the "Beast of Solomon", which turned out to be several beasts collecting for the Hellhouse. All the way through the scenario they were getting "interference" from... something else... it wasn´t making sense for them - there was some seriously freaky supernatural stuff going on which didn´t jibe with the beast hunt.
When the PC´s eventually met the source of the "interference" they realised just how weak and insignificant they were... it was an Unbound Daemonhost! This thing was hard as nails and really only played with the Player Characters, appearing and disappearing at will to ruin their day and cause havoc for some unknown reasons. As they were deep under Solomon at the time they couldn´t even reach their Inquisitor to squeal for help, being pretty much at this things mercy as it herded them toward trouble with the Hellhouse!
Of course, this is part of an ongoing plot - the Daemonhost needs them to accomplish a few deeds way down the line and is simply making sure that they are in the right place at the right time to be taken advantage of, tattered Fates fits nicely into this as it will take them into deep space. What they don´t know is that they will be having an encounter with a not-so-derelict ship as they return home (assuming they survive Tattered Fates that is!).
The point is that they felt that they were getting very tough and could face almost anything - when the Daemonhost turned up they realised just how wrong they were, it basically slapped them round like children and made it very clear that it was only playing with them. They could do very little or nothing to even scratch him.