I just played my second game using Innsmouth (and ALL other expansions of course!).
The GOO was Quachil Uttaus, doom was at 5, we had 3 seals, very few monsters out, only two open gates, all investigators well equipped and doing fine, plenty of clues still to gather. Seemed like a sure fire win.
We lost to the Third Act :-) Act I was drawn very early, so we just ignored it as usual. When Act II came out a couple of turns later, we only had one seal, so we were forced to let it happen. First time I have ever seen Act III.

