I know the rule book specifically states that during the final battle an investigator cannot focus dice or request assistance during the final battle. During my last few play sessions, I suspended this rule to see how it affects the final battle and found out that even with focusing or requesting assistance, the final battle is still challenging. Only once did it help in defeating the Ancient One. After all, it only makes sense that the investigators work together to defeat the Ancient One. Investigators aren't going to sit on the sidelines while one of their companions attacks.
I know the final battle is supposed to be difficult, but without focusing or requesting assistance, it can be almost impossible. If luck goes against the players and they can't prevent the Ancient One from awakening, at least give them some sense of hope!