The Dragon expansion is probably the most conducive Talisman variation for solo play if you use the Dragon Tower inner region. Choose one character, get a counter and give yourself 50, 75, or 100 turns (depending on difficulty level you wish) and play the way you normally would.
If you break through the portal of power within your allotted turns, you get to scale the tower and try to defeat the dragon king. If you run out of turns before you get to the inner region or lose all lives anywhere along the way, you lose.
Edited by John Steed