In all my years as a GM, I have never taken a canned game out for a spin without some kind of tweaking or twiddling or customizing. Sometimes it's pretty extensive (some of the chapters of Dawn of Defiance needed some serious work), sometimes very, very little.
Now, I haven't had a chance to look over Lost Knowledge yet beyond just a brief skim a couple of days ago - but I thought I'd see what you guys had in mind, what needs fleshing out, what needs pruning and explaining.