Just picked up the game at GenCon. Are there any particular cycles/sets I should focus on picking up to complement the core set?

Check out the blog Tales from the Cards. He has some buying guides up that you will probably find helpful.

The blog Epi Lepi was talking

http://talesfromthecards.wordpress.com/new-player-guides/

Thanks, I'll check that out.

I also just picked up the Core set...thanks for the link!