I don't have the Serena or Raythen packs yet, but is there anything in the rules that would prevent the Heroes from using Serena or Raythen as a Hero, and the OL using the same character's Plot deck and summoning them as an Agent?
Obviously this can't be done in the Labyrinth of Ruin campaign, but what about other campaigns? Mechanically, there'd be no problem with this, of course, but thematically it would be kind of weird.